Efficacy of high dose methotrexate in pediatric auto-immune uveitis
نویسندگان
چکیده
منابع مشابه
Efficacy of high dose methotrexate in pediatric auto-immune uveitis
Methods Retrospective analysis of 46 pediatric patients with uveitis with or without underlying systemic disease treated with MTX at the University Medical Center Groningen (The Netherlands ) between 1993 and 2013. The SUN (Standardization of Uveitis Nomenclature) workinggroup criteria were used for endpoints. Other endpoints included visual outcome, steroid-sparing effect, cumulative dose MTX ...
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Since the discovery that auto-antibodies to thyroglobulin were present in cases of Hashimoto's disease (Doniach and Roitt, 1957), a search for auto-antibodies has been made in various diseases of otherwise obscure origin. Ophthalmology has already provided the first confirmed example of an auto-antibody causing disease in the condition endophthalmitis phako-anaphylactica; a similar explanation ...
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Background: Idiopathic anterior uveitis is an anterior segment inflammation in which a detailed medical history, general and ocular physical examination is not associated with any defined clinical syndrome. Alterations in immune system parameters have been reported in patients with idiopathic posterior uveitis; however no data on the role of immune system in idiopathic anterior uveitis has yet ...
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High-dose methotrexate (HDMTX) added to a basic regimen of chemotherapy proved superior to cranial irradiation and sequentially administered drug pairs (RTSC) in prolonging complete remissions in children with "standard-risk" acute lymphocytic leukemia. To extend this result to more contemporary risk groups, we reclassified the patients according to methods of the Pediatric Oncology Group (POG)...
متن کاملIntra-vitreal injection of methotrexate in experimental endotoxin-induced uveitis in rabbit
Uveitis is a major cause of vision loss. Methotrexate (MTX) has been widely used in uveitis due to its relatively safe profile. The purpose of this study was to evaluate the effects of two different dosages of MTX via intra-vitreal administration for treatment of endotoxin induced uveitis (EIU) in an experimental model. Thirty-five healthy rabbits were randomly divided into four groups and all ...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2014
ISSN: 1546-0096
DOI: 10.1186/1546-0096-12-s1-p234